KMID : 0861120040080010115
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Korean Journal of Oriental Preventive Medicine 2004 Volume.8 No. 1 p.115 ~ p.133
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Effect of Hasuohwan(ù¼âÏè¡ü¯) on Antioxidant Capacity in D-galactose Induced Aging Rats
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Lee Jeong-Won
Lee Song-Shil Baek Jin-Woong Lee Sang-Jae Kim Kwang-Ho
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Abstract
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Hasuohwan(ù¼âÏè¡ü¯) composed of Polygonum multiflorum Thunb and some medical herbs are known as formula of senescence delay effect. The aim of this study is to investigate the effect of Hasuohwan(ù¼âÏè¡ü¯) on antioxidant enzyme activity such as Thiobarbituric acid reactive substance(TBARS) in rat plasma and liver, Superoxide dismutase(SOD), Glutathione peroxidase(GSH-px), Catalase(CAT) in rat erythrocyte and liver. Rats were sacrificed and TBARS was measured in rat plasma and liver. SOD, GSH-px and CAT were measured in rat erythrocytes and liver. TBARS in plasma concentrations of HSO group was significantly lower than those of control group. RBC and liver GSH-px activities of HSO group were significantly higher than those of control group. According to above results, it is considered that Hasuohwan is effective in inhibiting lipid peroxidation and increasing antioxidative enzyme activities in D-galactose induced aging rat. Therefore, Hsuohwan is considered in effective of senescence delay.
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KEYWORD
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Hasuohwan, Antioxidant Capaciyt, D-galactose Induced Aging Rat
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